Dailymed cardene iv nicardipine hydrochloride injection. Cardene, cardene iv nicardipine dosing, indications, interactions. A pharmacy workflow management system and automated compounding system can help streamline pharmacy operations. Current drug dosing charts for 48 of the most common, and most difficult to administer, intravenous infusion critical care drugs ensure that the information you need is readily available. Information in this booklet should be used as a guide only. Nicardipine 10 mg10 ml solution for injection is indicated for the treatment of acute lifethreatening. Current drug dosing charts for 48 of the most common, and most difficult to administer, intravenous infusion critical care drugs ensure that the information you need is readily. Medscape indicationspecific dosing for cardene, cardene iv nicardipine. Nicardipine yc93 is a calcium channel blocker that has been widely used to control blood pressure in severe hypertension following events such as ischemic. Patients are always placed on telemetry and noninvasive bp. Nicardipine is a calcium channel blocker that relaxes widens your blood vessels, which makes it easier for the heart to pump and reduces its workload nicardipine is used to treat hypertension high blood pressure and angina nicardipine may also be used for purposes not listed in this medication guide. Nicardipine has a greater selectivity for ltype calcium channels in vascular smooth muscle than cardiac myocytes. Though vastly different, these tools share a basic truth.
Premixed injection is available as a readytouse sterile, nonpyrogenic, clear, colorless to yellow, isoosmotic solution for intravenous administration in a 200 ml galaxy container with 20 mg 0. Maintenance2575 mcgkgmin infusion or incremental bolusesof1020mg. The compatibility of nicardipine hydrochloride injection. Iv, rapid reduction of bp in the management of acute severe hypertension and lifethreatening symptoms in children and adolescents. Nicardipine is a second generation calcium channel blocker used in the treatment of hypertension and stable angina pectoris. Compatibility of heparin sodium in intravenous line with. Key words heparin sodium, nicardipine, compatibility, injection via. Pocket reference for icu staff critical care medicine services 2000 2nd edition tripler army medical center. Nicardipene therapy has been associated with a low rate of transient serum enzyme elevations, but has not been linked convincingly to. To determine the physical compatibility of propofol injection with 77 other drug products using two methods not previously reported.
Cardene, cardene iv nicardipine dosing, indications. Cardene iv nicardipine hydrochloride premixed injection for intravenous use. Nicardipine demonstrates strong coronary and cerebral vasodilatory activity. In a case report of a 68kg girl, aged 14 years, with glomerulonephritis who was initially maintained on a nicardipine infusion dosing range. If transitioning to po nicardipine, initiate po dosing 1 hr before discontinuance of iv. If an oral antihypertensive agent other than nicardipine is to be used after iv nicardipine, initiate therapy upon discontinuation of iv nicardipine. Nicardipine relaxes widens your blood vessels, which makes it easier for the heart to pump and reduces its workload. Nicardipine cardene, cardene sr belongs to a class of drugs referred to as calcium channel blockers ccbs. Premixed injection for intravenous administration contains 20 mg of nicardipine hydrochloride per 200 ml 0. Nicardipine hydrochloride injection produces significant decreases in systemic vascular resistance. Cardene iv nicardipine hydrochloride premixed injection in 0. Cardene, cardene sr nicardipine uses, side effects.
Iv nicardipine was shown to be compatible and the shortterm. Nicardipine injection is compatible with the following iv solutions. There is no data regarding the conversion of nicardipine iv infusion to oral dosing in pediatric patients. Fully updated coverage includes the newest iv treatments with magnesium, conivaptan, potassium, and nicardipine, helping you provide the most effective care possible.
Based upon the trusted trissels 2 clinical pharmaceutics database by lawrence a. Intravenous administration of formulary medications. Includes drug interactions drugdrug, druglab test, drugfood, drugpregnancy, druglactation and drugalcohol interactions, trissels iv compatibility for single drugs or drug combinations. Three overdosages with nicardipine or nicardipine have been reported. Propofol compatibility with other intravenous drug products. Critical care intravenous drug administration guide. Nicardipine is prescribed for the treatment of high blood pressure and angina heart pain.
Two occurred in adults, 1 of whom ingested 600 mg of nicardipine and the other 2160 mg of nicardipine. Premixed injection is a calcium channel blocker indicated for the shortterm treatment of hypertension when oral therapy is not feasible. Transition from iv nicardipine to an oral antihypertensive agent. Critical care intravenous infusion drug handbook ebook. This iv drug compatibility chart is provided as a quick reference, however since information is subject to change it is advised that you check with a pharmacist for recommendations as well as product information to check for any changes or additional incompatibilities. Report any rhythm disturbances or symptoms of increased arrhythmias, including palpitations, chest pain, shortness of breath, fainting, and fatigueweakness. Cardene nicardipine hydrochloride is a calcium ion influx inhibitor slow channel blocker or calcium channel blocker. Intravenous compatibility chart free html5 flip book. Each of 77 drug products were mixed with 1 an equal volume of propofol injection, 2 an equal volume of propofol injection with methylene blue added, and 3 an equal volume of the separated aqueous phase of propofol injection. Nicardipine should be administered by continuous intravenous infusion only.
Nicardipine drug monograph pediatric care online aap. If oral nicardipine is to be used after iv nicardipine, administer the first dose 1 hour prior to discontinuation of the iv infusion. Assess heart rate, ecg, and heart sounds, especially during exercise see appendices g, h. Nicardipine 10mg10ml solution for injection summary of product. Nicardipine is a second generation slow calcium channel inhibitor, and belongs to the phenyldihydropyridine group. Cardene iv nicardipine hydrochloride premixed injection, for intravenous use initial u. It takes spikes, syringes, and pumps to make an intravenous iv solution. Drug monographs include detailed information on dosing for specific indications, adverse effects, comparative efficacy and pharmacokinetics. Initiate therapy at 5 mghour as a continuous iv infusion.
Management of chronic stable angina pectoris alone or in combination with other antianginal agents. Annex i list of the names, pharmaceutical form, strengths. Irregular heart beat, shortness of breath, swelling of the feet, pronounced dizziness, nausea, or drop in bp. Evaluation of intravenous cardenenicardipineand labetalol use in the emergency department clue the safety and scientific validity of this study is the responsibility of the study sponsor and investigators. The compatibility of nicardipine hydrochloride injection with various icu medications during simulated ysite injection. It belongs to the dihydropyridine class of calcium channel blockers. Intravenous nicardipine or invented name is indicated for the treatment of acute lifethreatening hypertension, particularly in the. Iv drug compatibility chart the iv drug compatibility chart is based on information from the handbook of injectable drugs, 16th edition, by lawrence a. Summary of product characteristics and package leaflet. Fda package insert for nicardipine contains no information regarding iv compatibility.
Nicardipine hydrochloride monograph for professionals. Propofol compatibility with other intravenous drug. Intravenous nicardipine quick reference cardene pdf. Studies in patients who received intravenous nicardipine. For prolonged control of blood pressure, transfer patients to oral medication as soon as their clinical condition permits. Pdf hospital pharmacies in many countries include a mix of both european and fda approved medications in their formulary. List item nicardipine article31 referral annex iii.
Incompatibilities are based on meeting any of the following criteria. Find patient medical information for nicardipine oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Cardene iv nicardipine hydrochloride injection label fda. A patient must have a central line available to receive these. Trissel, this tool provides clinicians with access to the information they need to answer tough compatibility questions within the workflow. Nicardipine side effects, dosage, interactions drugs. Medications information ciap clinical information access. Find patient medical information for nicardipine intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. It is available in by mouth and intravenous formulations. Iv geriatric patients, debilitated patients, or asa iii iv patients. Nicardipine 10mg10ml solution for injection summary of.